Meningioma microenvironment harbors a rich immune landscape with therapeutic implications (Bulk RNA-seq part)
GSE290805Guo et al., 2026
Mass General Brigham immune landscape cohort
Guo, Bi et al. (Neuro-Oncology 2026, PMID 41630100) profiled the meningioma immune microenvironment with a 9-sample single-cell RNA-seq set (8 of 9 samples with a WHO grade recorded: 1 grade 1, 6 grade 2, 1 grade 3) matched to a 47-sample bulk RNA-seq companion (grade breakdown 21 grade 1, 23 grade 2, 3 grade 3), both from Mass General Brigham. The two records are explicitly cross-linked via paired_multimodal. Strengths: real multi-modal matching from the same study and cohort, per-sample sex and grade already extracted for both records. Limitations: age is only partially parsed, anatomic location and treatment timepoint are not yet reported for either record.
Overview
- Modality
- Bulk RNA-seq
- Sample count
- 47
- Patient count
- Not reported
- Institution
- Mass General Brigham
- Corresponding author
- Wenya Linda Bi
- Platform
- Illumina HiSeq 2500 (GPL16791)
- Access type
- open
- Tissue preservation
- fresh_frozen
- WHO edition
- Not reported
Cohort detail
- Grade breakdown
- G1: 21 G2: 23 G3: 3
- Sex distribution
- 22 female, 25 male (n=47, extracted from GSM 'sex' field)
- Age distribution
- n=47 (range 22-87, median 57; extracted from GSM 'age' field)
- Anatomic location
- Not reported
- Brain invasion
- Not reported
- Normal/control tissue
- None
Priority attributes
WHO grade breakdown availableLinked to other modalitiesPeer-reviewed
Publications
- Guo X, et al. Meningioma microenvironment harbors a rich immune landscape that evolves with biological state. Neuro-oncology, 2026. PMID 41630100 · DOI