Meningioma microenvironment harbors a rich immune landscape with therapeutic implications (Single-cell RNA-seq part)
Mass General Brigham immune landscape cohort
Guo, Bi et al. (Neuro-Oncology 2026, PMID 41630100) profiled the meningioma immune microenvironment with a 9-sample single-cell RNA-seq set (8 of 9 samples with a WHO grade recorded: 1 grade 1, 6 grade 2, 1 grade 3) matched to a 47-sample bulk RNA-seq companion (grade breakdown 21 grade 1, 23 grade 2, 3 grade 3), both from Mass General Brigham. The two records are explicitly cross-linked via paired_multimodal. Strengths: real multi-modal matching from the same study and cohort, per-sample sex and grade already extracted for both records. Limitations: age is only partially parsed, anatomic location and treatment timepoint are not yet reported for either record.
Overview
- Modality
- scRNA-seq
- Sample count
- 9
- Patient count
- Not reported
- Institution
- Mass General Brigham
- Corresponding author
- Wenya Linda Bi
- Platform
- Illumina NovaSeq 6000 (GPL24676)
- Access type
- open
- Tissue preservation
- Not reported
- WHO edition
- Not reported
Cohort detail
- Grade breakdown
- G1: 1 G2: 6 G3: 1
- Sex distribution
- 5 male, 3 female, 1 not provided (n=9, extracted from GSM 'sex' field)
- Age distribution
- n=8 of 9 (range 38-83, median 67; 1 sample age not provided; extracted from GSM 'age' field)
- Anatomic location
- Not reported
- Brain invasion
- Not reported
- Normal/control tissue
- arachnoid (n=1)
Interactive gene-expression viewer
All 9 samples merged (unintegrated): 8 tumor + 1 arachnoid (normal control) · 51,011 cells, 150 genes, 9 samples merged.
All 9 samples (including the 1 non-tumor arachnoid control) were merged by raw concatenation, not batch-corrected/integrated (same approach ScPCA documents for its own merged objects) -- use "color by sample" to check for patient-driven rather than biological clustering, and note the arachnoid sample is a genuinely different tissue type mixed into the same embedding, not another tumor.
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Priority attributes
Publications
- Guo X, et al. Meningioma microenvironment harbors a rich immune landscape that evolves with biological state. Neuro-oncology, 2026. PMID 41630100 · DOI