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MENINGIOMA REGISTRY
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Genomic Characterization of Meningiomas

phs000552.v2.p1Brastianos et al., 2013
View on ncbi.nlm.nih.gov ↗

Overview

Modality
WGSWESTargeted panel sequencing
Sample count
65
Patient count
65
Institution
Massachusetts General Hospital / Dana-Farber Cancer Institute / Broad Institute
Corresponding author
Rameen Beroukhim, Ian F Dunn, William C Hahn
Platform
Illumina HiSeq 2000
Access type
controlled
Tissue preservation
Not reported
WHO edition
Not reported

Cohort detail

Grade breakdown
G1: 47 G2: 15 G3: 3
Sex distribution
12 male, 53 female (n=65 subjects)
Age distribution
Not reported
Anatomic location
Not reported
Brain invasion
Not reported
Normal/control tissue
matched germline blood (normal control used for somatic variant calling) (n=65)

Priority attributes

WHO grade breakdown availableLarge cohort (top quartile)Primary vs. recurrent annotatedMolecular subtype annotatedPeer-reviewed

Publications

  • Brastianos PK, et al. Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations. Nature Genetics, 2013. PMID 23334667 · DOI

Sources

  • ncbi.nlm.nih.gov
    https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000552.v2.p1
  • PubMed
    https://pubmed.ncbi.nlm.nih.gov/23334667/
  • DOI
    https://doi.org/10.1038/ng.2526
  • ftp.ncbi.nlm.nih.gov
    https://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000552/phs000552.v2.p1/GapExchange_phs000552.v2.p1.xml
  • ftp.ncbi.nlm.nih.gov
    https://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000552/phs000552.v2.p1/pheno_variable_summaries/phs000552.v2.pht003027.v1.p1.Meningiomas_Subject.var_report.xml
  • ftp.ncbi.nlm.nih.gov
    https://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs000552/phs000552.v2.p1/pheno_variable_summaries/phs000552.v2.pht003030.v1.p1.Meningiomas_Sample_Attributes.var_report.xml