Gene expression profile in meningioma patients at the single cell level
GSE278452Lee et al., 2025
Overview
- Modality
- snRNA-seq
- Sample count
- 14
- Patient count
- 7
- Institution
- Korea university
- Corresponding author
- Jason K Sa
- Platform
- Illumina HiSeq 2500 (GPL16791)
- Access type
- open
- Tissue preservation
- fresh_frozen
- WHO edition
- Not reported
Cohort detail
- Grade breakdown
- G1: 6 G2: not reported G3: not reported
- Sex distribution
- Not reported
- Age distribution
- Not reported
- Anatomic location
- Not reported
- Brain invasion
- Not reported
- Normal/control tissue
- None
Interactive gene-expression viewer
All 14 samples merged (7 patients, primary+recurrent), using the depositors' OWN published cell-type labels and UMAP coordinates · 74,979 cells, 100 genes, 14 samples merged.
Cluster labels here are the depositors' OWN published cell-type calls (Cancer cells, Macrophage, Fibroblasts, etc.), not this project's own marker-gene-based guesses -- higher confidence than the informal per-cluster labels used elsewhere in this viewer, since they come from the original study's own analysis.
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Priority attributes
WHO grade breakdown availableSingle-cell resolutionPrimary vs. recurrent annotatedMolecular subtype annotatedPeer-reviewed
Publications
- Lee JY, et al. Single-cell analysis reveals a longitudinal trajectory of meningioma evolution and heterogeneity. Nature communications, 2025. PMID 40593590 · DOI