wbi@bwh.harvard.edu

Meningioma methylation data

GSE270371Wang et al., 2024

Princess Margaret / Nassiri-Zadeh retrospective cohort

At 994 methylation samples and 384 RNA-seq samples (1,378 combined under the parent SuperSeries), this is the single largest cohort in the registry by sample count. Deposited by the Princess Margaret Cancer Centre group in June 2024 (made public in August 2024). Publication resolved: the linked paper is Wang, Patil, Landry et al., Molecular classification to refine surgical and radiotherapeutic decision-making in meningioma (Nature Medicine 2024, PMID 39169220), confirmed via a full-text search for the literal accession strings and an exact corresponding-author match on both paired records. A different, smaller (n=100) trial-cohort paper from the same senior authors was checked earlier and correctly ruled out as a false match. Both records are now fully corroborated against their live source.

Modality
DNA methylation (array)
Sample count
994
Patient count
Not reported
Institution
Princess Margaret Cancer Center
Corresponding author
Farshad Nassiri, Gelareh Zadeh
Platform
GPL23976
Access type
open
Tissue preservation
both
WHO edition
Not reported
Grade breakdown
Not reported
Sex distribution
Not reported
Age distribution
Not reported
Anatomic location
Not reported
Brain invasion
Not reported
Normal/control tissue
None
Linked to other modalitiesLarge cohort (top quartile)Molecular subtype annotatedOutcome/survival dataPeer-reviewed
  • Wang JZ, et al. Molecular classification to refine surgical and radiotherapeutic decision-making in meningioma. Nature Medicine, 2024. PMID 39169220 · DOI

Also related: GSE270375

Sources

  • GEO
    https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE270371
  • PubMed
    https://pubmed.ncbi.nlm.nih.gov/39169220/