Secreted Clusterin Inhibits Tumorigenesis by Modulating Tumor Cell and Macrophage in Human Meningioma
GSE206647Ke et al., 2024
Overview
- Modality
- scRNA-seq
- Sample count
- 18
- Patient count
- 13
- Institution
- Jinan University
- Corresponding author
- Hongyi Zhang, Oscar J Luo
- Platform
- 10x Chromium 3' v3 (Illumina NovaSeq 6000, GPL24676)
- Access type
- open
- Tissue preservation
- Not reported
- WHO edition
- Not reported
Cohort detail
- Grade breakdown
- G1: 8 G2: 4 G3: 4
- Sex distribution
- Not reported
- Age distribution
- Not reported
- Anatomic location
- Not reported
- Brain invasion
- Not reported
- Normal/control tissue
- meningeal (non-neoplastic) (n=2)
Interactive gene-expression viewer
All 18 single-cell samples merged (this record's own scope, per GSM inspection -- excludes 9 other GSMs under the same GSE that are unrelated bulk RNA-seq cell-line experiments, not part of this record's sample_count) · 164,181 cells, 50 genes, 18 samples merged.
All 18 samples were merged by raw concatenation, not batch-corrected/integrated (same approach ScPCA documents for its own merged objects) -- use "color by sample" to check for patient-driven rather than biological clustering. 26 Leiden clusters at this scale means several likely resolve to the same broad cell type rather than being 26 distinct identities.
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Priority attributes
WHO grade breakdown availableSingle-cell resolutionLarge cohort (top quartile)Peer-reviewed
Publications
- Ke C, et al. Secreted clusterin inhibits tumorigenesis by modulating tumor cells and macrophages in human meningioma. Neuro-oncology, 2024. PMID 38416702 · DOI