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MENINGIOMA REGISTRY
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Phosphoproteomic and Kinomic Signature of Clinically Aggressive Grade I (1.5) Meningiomas Reveals RB1 Signaling as a Novel Mediator and Biomarker

10.1158/1078-0432.22471806.v1, 10.1158/1078-0432.22471809.v1, 10.1158/1078-0432.22471812.v1, 10.1158/1078-0432.22471815.v1Parada et al., 2020
View on Figshare ↗

Overview

Modality
Proteomics (bulk MS)
Sample count
85
Patient count
85
Institution
University of Washington School of Medicine (Dept. of Neurosurgery / Dept. of Pathology), Seattle
Corresponding author
Manuel Ferreira Jr
Platform
iTRAQ 4-plex isobaric labeling LC-MS/MS (phosphoproteomics, Table S6); PamStation/peptide-chip kinome array (Table S7)
Access type
open
Tissue preservation
Not reported
WHO edition
Not reported

Cohort detail

Grade breakdown
G1: 31 G2: 26 G3: 4
Sex distribution
Reported per-sample in Table S3/S4 'Demography' free-text field (e.g. '75 F'); not aggregated in this review
Age distribution
Reported per-sample in Table S3/S4 'Demography' free-text field; not aggregated in this review
Anatomic location
Per-sample free-text location field in Table S3/S4 (e.g. left orbital roof/basal frontal, right parietal parafalcine, extra-axial foramen magnum, falx and parasagittal, convexity, CPA); not aggregated into the controlled vocabulary's anatomic categories here
Brain invasion
Invasion column present in Table S3/S4 per-sample annotation ('yes'/'no'/'NA'); exact aggregate counts not tabulated in this review, present at the individual-sample level in the downloaded file
Normal/control tissue
None

Priority attributes

WHO grade breakdown availableLarge cohort (top quartile)Outcome/survival dataPeer-reviewed

Publications

  • Parada CA, et al. Phosphoproteomic and Kinomic Signature of Clinically Aggressive Grade I (1.5) Meningiomas Reveals RB1 Signaling as a Novel Mediator and Biomarker. Clinical Cancer Research, 2020. PMID 31615938 · DOI

Sources

  • Figshare
    https://aacr.figshare.com/articles/dataset/Supplementary_Data_from_Phosphoproteomic_and_Kinomic_Signature_of_Clinically_Aggressive_Grade_I_1_5_Meningiomas_Reveals_RB1_Signaling_as_a_Novel_Mediator_and_Biomarker/22471806
  • Figshare
    https://aacr.figshare.com/articles/dataset/Supplementary_Data_from_Phosphoproteomic_and_Kinomic_Signature_of_Clinically_Aggressive_Grade_I_1_5_Meningiomas_Reveals_RB1_Signaling_as_a_Novel_Mediator_and_Biomarker/22471809
  • Figshare
    https://aacr.figshare.com/articles/dataset/Supplementary_Data_from_Phosphoproteomic_and_Kinomic_Signature_of_Clinically_Aggressive_Grade_I_1_5_Meningiomas_Reveals_RB1_Signaling_as_a_Novel_Mediator_and_Biomarker/22471812
  • Figshare
    https://aacr.figshare.com/articles/dataset/Supplementary_Data_from_Phosphoproteomic_and_Kinomic_Signature_of_Clinically_Aggressive_Grade_I_1_5_Meningiomas_Reveals_RB1_Signaling_as_a_Novel_Mediator_and_Biomarker/22471815
  • PubMed
    https://pubmed.ncbi.nlm.nih.gov/31615938/
  • DOI
    https://doi.org/10.1158/1078-0432.CCR-18-0641